Movies Like Slither
If you loved Slither's Horror and Science Fiction storytelling, these films deliver a similar experience — carefully selected for tone, themes, and emotional depth. Each pick includes where to watch it right now.
★ Top Picks

Freaks of Nature
In the town of Dillford, humans, vampires and zombies were all living in peace - until the alien apocalypse arrived. Now three teenagers-one human, one vampire, and one zombie-have to team up to figure out how to get rid of the visitors.

PG: Psycho Goreman
Siblings Mimi and Luke unwittingly resurrect an ancient alien overlord. Using a magical amulet, they force the monster to obey their childish whims, and accidentally attract a rogues’ gallery of intergalactic assassins to small-town suburbia.

The Blob
In Arborville, California, three high school students try to protect their hometown from a gelatinous alien life form that engulfs everything it touches.

Feast
When a motley crew of strangers find themselves trapped in an isolated tavern, they must band together in a battle for survival against a family of flesh-hungry creatures.

The Fly
When Seth Brundle makes a huge scientific and technological breakthrough in teleportation, he decides to test it on himself. Unbeknownst to him, a common housefly manages to get inside the device and the two become one.

Creepshow
Five grisly tales from a 1950s-style comic, including a murdered father rising from beyond, a bizarre meteor, a vengeful husband, a mysterious crate's occupant, and a plague of cockroaches.

Resident Evil: Welcome to Raccoon City
Once the booming home of pharmaceutical giant Umbrella Corporation, Raccoon City is now a dying Midwestern town. The company’s exodus left the city a wasteland…with great evil brewing below the surface. When that evil is unleashed, the townspeople are forever…changed…and a small group of survivors must work together to uncover the truth behind Umbrella and make it through the night.

Night of the Creeps
In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.
More Movies Like Slither

Cold Storage
When a mutating, highly contagious fungus escapes a sealed facility, two employees – joined by a grizzled bioterror operative – must survive the wildest night shift ever to save humanity from extinction.

The Void
In the middle of a routine patrol, officer Daniel Carter happens upon a blood-soaked figure limping down a deserted stretch of road. He rushes the young man to a nearby rural hospital staffed by a skeleton crew, only to discover that patients and personnel are transforming into something inhuman. As the horror intensifies, Carter leads the other survivors on a hellish voyage into the subterranean depths of the hospital in a desperate bid to end the nightmare before it's too late.

Resident Evil
When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak.

Love and Monsters
Seven years since the Monsterpocalypse began, Joel Dawson has been living underground in order to survive. But after reconnecting over radio with his high school girlfriend Aimee, Joel decides to venture out to reunite with her, despite all the dangerous monsters that stand in his way.

The Thing
When paleontologist Kate Lloyd travels to an isolated outpost in Antarctica for the expedition of a lifetime, she joins an international team that unearths a remarkable discovery. Their elation quickly turns to fear as they realize that their experiment has freed a mysterious being from its frozen prison. Paranoia spreads like an epidemic as a creature that can mimic anything it touches will pit human against human as it tries to survive and flourish in this spine-tingling thriller.

Splinter
When their plans for a nature trip go awry, Polly and boyfriend Seth decide to check into a motel. On their way, they're carjacked and kidnapped by low-rent crooks Dennis and Lacey, who take the victims and their SUV to a nearby gas station. Along the way, they encounter an increasingly terrifying horde of parasites, and if any of them intend to survive, they'll have to outsmart the deadly organisms.

The Blob
A drive-in favorite, this sci-fi classic follows teenagers Steve and his best girl, Jane, as they try to protect their hometown from a gelatinous alien life form that engulfs everything it touches. The first to discover the substance and live to tell about it, Steve and Jane witness the blob destroying an elderly man, then it growing to a terrifying size. But no one else has seen the goo, and policeman Dave refuses to believe the kids without proof.

Die Alone
Lost in a world reclaimed by nature and overrun by mysterious creatures, Ethan, a young man with amnesia navigates the dangerous landscape in search of his lost love Emma. His journey takes an unexpected turn when he encounters Mae, a hardened and eccentric survivor. Together, Ethan and Mae face threats both human and otherwise before a fateful encounter with Kai unravels a secret that lies just beyond Ethan's fractured memory.

Color Out of Space
The Gardner family moves to a remote farmstead in rural New England to escape the hustle of the 21st century. They are busy adapting to their new life when a meteorite crashes into their front yard, melts into the earth, and infects both the land and the properties of space-time with a strange, otherworldly colour. To their horror, the family discovers this alien force is gradually mutating every life form that it touches—including them.

Alligator
A baby alligator is flushed down a toilet and survives by eating discarded lab animals that have been injected with growth hormones. The now gigantic animal escapes the city sewers and goes on a rampage, pursued by a cop and a big-game hunter.

Tremors
Val McKee and Earl Bassett are in a fight for their lives when they discover that their desolate town has been infested with gigantic, man-eating creatures that live below the ground.

Extinction
And suddenly, overnight, the world came to a halt. Two men, two survivors, one kid, and hatred that separates them. A place forgotten by everyone, including the creatures that inhabit the Earth... until now.
Why These Movies Are Similar
These recommendations share core qualities with Slither (2006): Horror and Science Fiction themes, similar narrative structure, and comparable emotional depth. NoBadPicks uses a combination of TMDB collaborative filtering, genre matching, and AI analysis to surface films most likely to resonate with fans of Slither.
See full details for Slither (2006)