Anime Like Sealab 2021
If you loved Sealab 2021's Animation and Comedy storytelling, these anime deliver a similar experience — selected for art style, narrative depth, and emotional impact. Each includes where to stream it now.
★ Top Picks

Kiff
This series follows Kiff, an optimistic squirrel whose best intentions often lead to complete chaos, and her best friend Barry, a sweet and mellow bunny. Set in the bustling mountains, where animals and magical creatures live together in harmony, the series features the duo, who take the town by storm with their endless adventures and zest for life.

Clerks
The continuing adventures of store clerks Dante and Randal, who try to make the best of their menial labor, with no help from Jay and Silent Bob.

Code Monkeys
Set in the early 1980s, Code Monkeys follows the adventures of fictional video game company GameAVision.

Animaniacs
Yakko, Wakko and Dot return for all-new big laughs and the occasional epic takedown of authority figures in serious need of an ego check. Joining the Warners are Starbox & Cindy on their latest play date while Pinky and the Brain's ideas for world domination lead them to all new adventures.

Ugly Americans
Social worker Mark Lilly helps new citizens—both human and "other"—begin the process of adapting to life in the Big Apple, but his coworkers, demonic bureaucrat Twayne, drunken wizard Leonard Powers, surly law enforcement head Frank Grimes & his girlfriend, Callie, don't make it easy.

Home Movies
TV series about the life of Brendon Small, an eight-year-old visionary who, using his friends Jason and Melissa as actors, have managed to direct over a thousand homemade films. His parents are divorced, but it doesn't feel strange since so many other kids' parents are divorced. His friend Jason actually feels upset because his parents are still together. At school, he is taught soccer by his coach John McGuirk, or as he calls him, "that weird Irish guy".

Chowder
An aspiring young chef named Chowder has adventures as an apprentice in Mung Daal's catering company. Although he means well, Chowder often finds himself in predicaments due to his perpetual appetite and his nature as a scatterbrain. He is also pestered by Panini, the apprentice of Mung's rival Endive, who wants Chowder to be her boyfriend, which he abhors.

Fish Hooks
This inventive animated comedy series, set inside a giant fish tank in Bud's Pet Shop, presents high school life as seen through the eyes of three BFFs (best fish friends), Bea, Milo and Oscar. Together they experience the typical life challenges and triumphs, including friendship, dating and sports, along with more atypical situations such as giant lobster attacks and, with the use of special land suits, school field trips to the hamster cages. The series was created by children's book illustrator Noah Z. Jones and features a notable voice cast. It's produced using an innovative mixture of digital animation and photo collage
More Anime Like Sealab 2021

Rugrats
A reinvention of the beloved 90s cartoon, Rugrats follows a group of adventurous babies as they discover the big world around them. Lead by Tommy Pickles, this toddler crew explores the world from their pint-sized and wildly imaginative perspective.

I Am Weasel
The adventures of the noble, generous, intelligent and good-at-everything I.M. Weasel, who must compete once again with his arch-enemy, the bumbling, brainless and utterly talentless I.R. Baboon.

Aqua Teen Hunger Force
The surreal adventures of three anthropomorphic fast food items: Master Shake, Frylock and Meatwad, and their human nextdoor neighbor, Carl Brutananadilewski.

The Weekenders
Four friends, Tino, Carver, Lor, and Tish, spend each weekend discovering and creating new levels of fun, while negotiating the obligatory obstacles of adolescence.

MAD
Mad is an American animated sketch comedy series created by Kevin Shinick and produced by Warner Bros. Animation. Based upon the magazine of the same name, each episode is a collection of short animated parodies of television shows, movies, games, celebrities, and other media using various types of animation instead of the usual animation style that Warner Bros. Animation is known for. The series premiered on the evening of September 6, 2010 on Cartoon Network. It has been described as a "kid-friendly version of Robot Chicken".

My Gym Partner's a Monkey
My Gym Partner's a Monkey is an American animated television series created by Tim Cahill and Julie McNally-Cahill and produced by Cartoon Network Studios. The story revolves around Adam Lyon, a human who, after a clerical error listed his surname as "Lion," is forced to transfer to Charles Darwin Middle School, a school for local anthropomorphic zoo animals, where he is partnered with Jake Spidermonkey in gym, with whom he quickly becomes best friends.


Metalocalypse
Part-American, part-Scandinavian death-metal band Dethklok has a lingering effect on its fans, who take the words seriously and do anything Dethklok lyrics say. The government fears the band's influence and sets out to destroy it by covert means; for example, by sending military pharmaceutical psychotropic drug manufacturers. Deemed sociopaths for tossing hot coffee at their concert attendees, two of the band members are alcoholics, and they all have self-esteem issues.

Squidbillies
Squidbillies is an animated television series about the Cuylers, an impoverished family of anthropomorphic hillbilly mud squids living in the Appalachian region of Georgia's mountains. The show is produced by Williams Street Studios for the Adult Swim programming block of Cartoon Network and premiered on October 16, 2005. It is written by Dave Willis, co-creator of Aqua Teen Hunger Force, and Jim Fortier, previously of The Brak Show, both of whom worked on the Adult Swim series Space Ghost Coast to Coast. The animation is done by Awesome Incorporated, with background design by Ben Prisk.

Close Enough
A surreal take on transitioning from 20-something to 30-something centering on a married couple juggling such everyday challenges as parenthood, friendship, ham theft, stripper clowns and choosing the right day care.

China, IL
China, IL – meaning "China, Illinois" – is an animated television series for the cable network Adult Swim. The series is created by Brad Neely, and features Neely's existing characters from the China, IL web series and special. Characters include Frank and Steve Smith, aka "The Professor Brothers," and Mark "Baby" Cakes. Neely provides the voice for all three characters. The series is produced by Williams Street and animated by Titmouse, Inc. China, IL has been renewed for a second season with the possibility of a new half-hour runtime. On May 25, 2008, Adult Swim ran The Funeral, an 11-minute special which was streamed on the now defunct Super Deluxe website. The special combined Brad Neely's Professor Brothers and Baby Cakes webseries, which were also streamed at Super Deluxe, and established a larger environment for the characters. The special, as well as Brad Neely's other videos, can be viewed at Neely's YouTube page.

Mickey Mouse
In this series of cartoon shorts, Mickey Mouse finds himself in silly situations all around the world! From New York to Paris to Tokyo, Mickey experiences new adventures with his friends!
Why These Anime Are Similar
These recommendations share core qualities with Sealab 2021 (2000): Animation and Comedy themes, comparable animation style, and similar narrative pacing. NoBadPicks uses TMDB collaborative filtering, genre matching, and AI analysis to surface anime most likely to resonate with fans of Sealab 2021.
See full details for Sealab 2021 (2000)