Anime Like The Big C
If you loved The Big C's Comedy and Drama storytelling, these anime deliver a similar experience — selected for art style, narrative depth, and emotional impact. Each includes where to stream it now.
★ Top Picks

Claws
Follow the life and crimes of five diverse and treacherous manicurists working at the Nail Artisan of Manatee County salon, where there is a lot more going on than silk wraps and pedicures.

Life Sentence
When Stella finds out her terminal cancer is cured, she's going to have to learn to live with all the choices she's made when she decided to "live like she was dying".

And Just Like That…
This new chapter of “Sex and the City” follows Carrie, Miranda and Charlotte as they navigate the journey from the complicated reality of life and friendship in their 30s to the even more complicated reality of life and friendship in their 50s.

Divorce
A middle-aged couple experience the pain, the relief and the trials and tribulations of a divorce in this dry, witty comedy.

The Facts of Life
Mrs. Edna Garrett, housemother and dietitian at the Eastland School, teaches a group of girls in her charge how to solve those problems that every teenager has to face.

Men at Work
Men at Work is an American comedy series that airs on TBS. The series was created by Breckin Meyer and stars Danny Masterson, Michael Cassidy, Adam Busch, James Lesure and Meredith Hagner. The series premiered on May 24, 2012 at 10 pm. TBS second season premiered on April 4, 2013 with another 10 episode season.

HAPPYish
Thom Payne is a 44 year-old man whose world is thrown into disarray when his 25 year-old "wunderkind" boss arrives, saying things like "digital," "social" and "viral." Is he in need of a "rebranding," or does he just have a "low joy ceiling?" Maybe pursuing happiness is a fool's errand? Happiness after all is pretty high bar. In a world as absurd as ours, maybe the best anyone can hope for is happyish.

'Til Death
A comedy about the triumphs and tribulations of marriage and friendship from very different perspectives. It's about the funny – and sometimes annoying – things that happen between husbands, wives, parents, children, neighbors and friends day after day after day. The show focuses on Eddie and Joy Stark, a couple married for 23 years who live in Philadelphia, Pennsylvania.
More Anime Like The Big C

Shining Vale
A dysfunctional family moves from the city to a small town into a house in which terrible atrocities have taken place. But no one seems to notice except for Patricia “Pat” Phelps, who’s convinced she’s either depressed or possessed – turns out, the symptoms are exactly the same.

After Life
Tony had a perfect life. But after his wife Lisa suddenly dies, Tony changes. After contemplating taking his own life, he decides instead to live long enough to punish the world by saying and doing whatever he likes from now on.

Father Knows Best
Family man Jim Anderson copes with the everyday problems among his wife Margaret and their three children as they experience day-to-day changes.

Kidding
Jeff, aka Mr. Pickles, is an icon of children's TV. But when his family begins to implode, Jeff finds no fairy tale or fable or puppet will guide him through this crisis, which advances faster than his means to cope. The result: a kind man in a cruel world faces a slow leak of sanity as hilarious as it is heartbreaking.

How I Met Your Father
In the near future, Sophie tells her son the story of how she met his father: a story that catapults us back to the year 2021 where Sophie and her close-knit group of friends are in the midst of figuring out who they are, what they want out of life, and how to fall in love in the age of dating apps and limitless options.

Wilfred
Everyone else sees Wilfred as just a dog, but Ryan sees a crude and somewhat surly, yet irrepressibly brave and honest Australian bloke in a cheap dog suit. While leading him through a series of comedic and existential adventures, Wilfred the dog shows Ryan the man how to overcome his fears and joyfully embrace the unpredictability and insanity of the world around him.

Big School
A comedy about a dysfunctional staff room, unrequited love and interactive whiteboards set in an urban secondary school. Chemistry teacher Mr. Church is hopelessly in love with the school's new French teacher, who in turn is being chased by a lothario gym teacher.

The Steve Harvey Show
Down on his luck and out of money, former R&B star Steve Hightower lands a music teacher gig at an inner-city Chicago school. Showing who's in charge with his unorthodox approach, Steve discovers a new groove at Washington High School.

Tyler Perry's Sistas
There's nothing that bonds a group of single black women together more than sidestepping the land mines of living, working and dating in Atlanta. In a sea of swipe-lefts, social media drama and unrealistic #relationshipgoals, these friends try to find their Mr. Right.

Sirens
Worried about her sister's too-close relationship with her billionaire boss, a scrappy everywoman seeks answers at a lavish seaside estate.

Elsbeth
After her successful career in Chicago, Elsbeth Tascioni, an astute but unconventional attorney, utilizes her singular point of view to make unique observations and corner brilliant criminals alongside the NYPD.

The Premise
This anthology series about timeless moral questions in unprecedented times, takes provocative concepts and brings them into the open, delivering three-dimensional, character-driven stories with humor and heart.
Why These Anime Are Similar
These recommendations share core qualities with The Big C (2010): Comedy and Drama themes, comparable animation style, and similar narrative pacing. NoBadPicks uses TMDB collaborative filtering, genre matching, and AI analysis to surface anime most likely to resonate with fans of The Big C.
See full details for The Big C (2010)