Anime Like Samantha Who?
If you loved Samantha Who?'s Comedy storytelling, these anime deliver a similar experience — selected for art style, narrative depth, and emotional impact. Each includes where to stream it now.
★ Top Picks

My Name Is Earl
When petty criminal Earl Hickey wins the lottery, he sets off on a quest to repair his questionable karma.

Alexa & Katie
Lifelong best friends Alexa and Katie are eagerly anticipating the start of their freshman year of high school. The pals confront a crisis that leaves them feeling like outsiders at a time when what seems to matter most is fitting in.

The Unicorn
A tight-knit group of best friends and family helps Wade embrace his “new normal” in the wake of the loss of his wife. As a sometimes ill-equipped but always devoted single parent to his two adolescent daughters, he is taking the major step of dating again.

Happy Days
In 1950s Milwaukee the Cunningham family must contend with Fonzie, a motorcycle riding Casanova.

Sprung
A convicted criminal is determined to turn his life around after serving more than two decades in prison. When he is released unexpectedly from prison due to the pandemic with no place to live and the world on lockdown, Jack shelters-in-place with an unlikely group of former inmates, who band together and use their criminal expertise for good.

Nick Cannon Presents: Wild 'N Out
Nick Cannon and an A-list celebrity lead a team of improv comedians as they compete against each other.

The Dick Van Dyke Show
The Dick Van Dyke Show centers around the work and home life of television comedy writer Rob Petrie. The plots generally revolve around problems at work, where Rob got into various comedic jams with fellow writers Buddy Sorrell, Sally Rogers and producer Mel Cooley.
More Anime Like Samantha Who?

How I Met Your Mother
A father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.

Not Dead Yet
Nell Serrano is a broke and newly single self-described disaster. She works to restart the life and career she left behind some 10 years ago. When writing obituaries is the only job she can find, Nell starts getting life advice from an unlikely (and dead) source.

B Positive
Faced with finding a kidney donor, newly divorced dad Drew is at the end of his rope when he runs into Gina, a rough-around-the edges woman from his past who volunteers her own. Together they form an unlikely bond and begin a journey that will change both of their lives.

Will & Grace
Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.

One Day at a Time
The misadventures of a divorced mother, two teenage daughters, and new building superintendent in Indianapolis.

Agatha Raisin
Burnt out on office politics, Agatha Raisin retires early to a picturesque village in the Cotswolds and soon finds a second career as an amateur detective investigating mischief, mayhem, and murder in her deceptively quaint town.

Three's Company
When two single girls, Janet and Chrissy, need a roommate to share their Santa Monica apartment, they decide to offer a room to Jack, a man they find passed out in the bathtub after the going-away party for their last roommate. However, hijinks ensure when Jack must pretend to be gay in order to throw off the scent of the trio's conservative landlady.

The Brady Bunch
When widower Mike Brady marries a lovely lady widow Carol Ann, their two families become one. These are the misadventures of this new couple, their six children, a dog named Tiger, and quirky housekeeper Alice.

Seinfeld
A stand-up comedian and his three offbeat friends weather the pitfalls and payoffs of life in New York City in the '90s. It's a show about nothing.

Shifting Gears
Matt is a stubborn, widowed owner of a classic car restoration shop. When Matt's estranged daughter Riley and her teenage kids move into his house, the real restoration begins.

Sonny with a Chance
Allison "Sonny" Munroe makes the leap from the Midwest to Los Angeles to join the cast of "So Random!," the most popular sketch comedy TV show for kids and tweens. Her fellow young actors are resident teen queen Tawni, super suave Nico, gregarious funnyman Grady and quirky Zora. Now Sonny must somehow balance these new friendships while adjusting to her family's decidedly different way of life in Hollywood. Meanwhile, Sonny must also contend with heartthrob Chad Dylan Cooper, star of the rival show "MacKenzie Falls," who makes it known that he thinks his dramatic work is better than her comedy career.

The Big Bang Theory
Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.
Why These Anime Are Similar
These recommendations share core qualities with Samantha Who? (2007): Comedy themes, comparable animation style, and similar narrative pacing. NoBadPicks uses TMDB collaborative filtering, genre matching, and AI analysis to surface anime most likely to resonate with fans of Samantha Who?.
See full details for Samantha Who? (2007)
